A psychobiotic for mental wellness
Two thirds of adults aged 18 to 54 report feeling stressed.1 At the same time, research is increasingly supporting the positive role of probiotics on mental wellness and cognitive health.2 When the knock-on effects of daily stress include disruption to sleep quality, deficits in concentration and attention, and a greater susceptibility to develop low mood and anxiety, it is clear we need a targeted solution. Introducing ProbioBrain™, a next generation probiotic solution with the unique Bifidobacterium longum 1714® strain.
Uniquely positioned to meet the needs of a growing market
The brain health supplement market is forecast to grow at a compound annual growth rate (CAGR) of 8.3% by 2025.
of consumers think well-being is the #1 priority for overall health.5
of industry experts believe cognition related lifestyle conditions will be a key trend.
of consumers associate probiotics with cognitive health.
What is the gut-brain axis and what are psychobiotics?
The gut-brain axis is a biological network comprising the gut (gastrointestinal tract), the enteric nervous system (our ‘second brain’ which regulates gastrointestinal function), and the brain. Bidirectional communication along this network is critical for regulation of important functions in the body such as immunity, digestion, metabolism, satiety, and the stress response.17 The vagus nerve is a long, wandering nerve extending from the brainstem in the back of the brain into organs located in the neck, chest, and abdomen, including the intestines. The vagus nerve not only carries signals from the brain but also carries sensory signals from the gut back to the brain. This allows the brain to sense the environment within the gut! Microbes within the gut can produce neurotransmitters and neuroactive molecules that can influence the brain. The scientific evidence shows that our gut microbes can influence how our brain functions, how we respond to stress, our mood, and even how we behave.18,19 The microbiota-gut-brain axis therefore plays an essential role in our overall health, including mental wellness and cognitive health.
What’s exciting is that this very signaling system is paving the way for pioneering supplements that can improve everyday health concerns with a mental component. One area of interest is the growing body of research on psychobiotics. Psychobiotics is a term to describe any exogenous influence (i.e., probiotics, prebiotics, dietary fiber) whose positive effect on mental health is bacterially mediated.16
A safe solution that positively influences everyday stress
Our unique Bifidobacterium longum 1714® culture is of human origin and was discovered in the human gut. This already tells us something about this strain – it is safe and naturally present in the healthy human gut. ProbioBrain™ was isolated and developed over many years of research with the gut-brain axis specifically in mind. The first-in-class technology behind the strain has been developed in collaboration with prestigious institutions and internationally renowned experts in neuroscience. You can find out more about our published clinical research, below. Beyond these publications, our team continues to investigate the effects of Bifidobacterium longum 1714® on brain health with several clinical trials currently ongoing in sleep, mood, and well-being.
How ProbioBrain™ works in the body
ProbioBrain™ with Bifidobacterium longum 1714® targets the gut-brain axis and has been shown in two placebo-controlled clinical trials to:
- Help adults handle the psychological and physical responses to stress.
- Significantly reduce cortisol output in response to stress.
- Maintain a calm state of mind and emotional balance during stressful times.
Listen to Dr. Paul Enck discuss our clinical findings
Dr. Paul Enck discusses the surprising results of research undertaken at his lab in Tübingen University to investigate the effects of B.longum 1714® on stress and the gut-brain axis.
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Novozymes OneHealth proprietary insights, 2019, N=500